乳头状甲状腺癌基质金属蛋白酶-9 的表达意义

Signif icance of Matrix Metalloproteinase-9 Expression in Human Papillary Thyroid Carcinomas

摘要: 目的　探讨乳头状甲状腺癌基质金属蛋白酶-9 (MMP-9) 表达的临床意义。方法　采用SP 免疫组化方法检测62 例乳头状甲状腺癌及28 例相应癌转移淋巴结MMP-9 的表达,分析其与临床病理特性的关系。结果　乳头状甲状腺癌MMP-9 阳性表达率为79. 0 %(49/ 62), 并且随着浸润程度的加深和淋巴结转移的出现而逐渐增强(均P < 0. 05) ;癌转移淋巴结MMP-9 阳性表达率为100. 0 %(28/ 28), 与相应原发癌灶同步表达。结论　MMP-9 过度表达与乳头状甲状腺癌的浸润和淋巴结转移密切相关。

Abstract: Objective 　To investigate the significance of matrixmetalloproteinase-9 expression in human papillary thyroid carcinomas (PTC) . Methods 　The expression of MMP-9 was detected immunohistochemically in 62 PTC and 28 lymph nodes with corresponding cancer metastasis. The association was analysed between the positive rate of MMP-9 and the clinicopathologic features of PTC. Results 　The positive rate of MMP-9 expression was 79. 0 % ( 49/ 62 ) and 100. 0 % (28/ 28) in primary PTC and metastatic lymph nodes respectively. The expression of MMP-9 was enhanced with the increase of the depth of invasion and lymph node metastasis. Conclusion 　The overexpression of MMP-9 was significantlycorrelated with invasion and lymph node metastasis of PTC.