Abstract: Objective To study the efficacy of continuous infusion of cisplatin and oral etoposide in the treatment of non-small-cell lung cancer (NSCLC). Methods 61 cases with NSCLC(stage Ⅲ-Ⅳ)were randomized into treated group(TG,33 cases)and control group(CG,28 cases).CG was treated with conventional EP regimen.TG was treated with cisplatin (20mg/m2 daily for 4 days by i.v. continuous infusion)and etoposide capsules(50mg orally,twice daily for 10 days). Results The response rate (CR+PR) of TG(57.6%) was significantly higher than that of CG(32.1%，P<0.05).The incidence of nausea and emesis in TG(15.1%)was significantly lower than that in CG(46.4%，P<0.01).Kidney disfunction occurred less in TG. The quality of life in TG was improved better than that in CG(P<0.05). Conclusion The efficacy of continuous infusion of cisplatin and oral etoposide in the treatment of advanced NSCLC was better than that of conventional EP regimen.There were less side effects in the regimen.It was on effective,safe treatment for advanced NSCLC.