COX-2和bcl-2异常表达与鼻咽癌生物学行为的关系

COX-2 and bcl-2 Expression and Their Relations to the Behavior of Nasopharyngeal Carcinoma

摘要: 目的探讨环氧化酶-2(COX-2)、bcl-2在鼻咽癌中的表达及其与生物学行为的关系。方法选取临床资料完整并随访达5年以上的86例鼻咽癌患者,采用免疫组化技术检测活检标本中COX-2及抗凋亡蛋白bcl-2的表达,并分析其与临床病理及预后的相关性。结果COX-2在鼻咽癌组织中阳性表达率为73.3%(63/86),与原发灶范围、颈淋巴结转移、肿瘤分级、生存期密切相关(P<0.05);bcl-2蛋白阳性表达率为84.9%(73/86),与组织学类型、肿瘤分级、病灶范围、淋巴结转移均无相关性,但生存期≤5年组bcl-2蛋白表达阳性率显著高于生存期>5年组(P<0.05)。结论COX-2在鼻咽癌组织中高表达,可能参与了鼻咽癌的发生发展过程,可作为判断预后的一种有用指标;bcl-2的表达可能与鼻咽癌病因学有关,在鼻咽癌病程中的作用有待进一步探讨。

Abstract: Objective To study the expression of cyclooxygenase-2 ( COX-2 ) and bcl-2 in nasopharyngeal carcinoma(NPC) and their relations to the clinicopathological features. Methods COX-2 and bcl-2 protein expression in 86 cases of nasopharyngeal carcinoma was examined by using immunohistochemical staining.All cases had been followed up 5 years. Results The overexpression rate of COX-2 in NPC was 73.3% (63/86) and it was correlated to primary tumor stage,lymph node metastasis,pathological grade,clinicopathological stag...