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国产多西他赛为主的联合化疗治疗转移性乳腺癌

张 军, 梁亚军, 胡长耀

张 军, 梁亚军, 胡长耀. 国产多西他赛为主的联合化疗治疗转移性乳腺癌[J]. 肿瘤防治研究, 2007, 34(10): 780-782. DOI: 10.3971/j.issn.1000-8578.3244
引用本文: 张 军, 梁亚军, 胡长耀. 国产多西他赛为主的联合化疗治疗转移性乳腺癌[J]. 肿瘤防治研究, 2007, 34(10): 780-782. DOI: 10.3971/j.issn.1000-8578.3244
ZHANG Jun, LIANG Ya-jun, HU Chang-yao. Domestic Docetaxel-based Combination Chemotherapy in Treatment of Metastatic Breast Cancer[J]. Cancer Research on Prevention and Treatment, 2007, 34(10): 780-782. DOI: 10.3971/j.issn.1000-8578.3244
Citation: ZHANG Jun, LIANG Ya-jun, HU Chang-yao. Domestic Docetaxel-based Combination Chemotherapy in Treatment of Metastatic Breast Cancer[J]. Cancer Research on Prevention and Treatment, 2007, 34(10): 780-782. DOI: 10.3971/j.issn.1000-8578.3244

国产多西他赛为主的联合化疗治疗转移性乳腺癌

详细信息
    通讯作者:

    张 军

  • 中图分类号: R737. 9 ;R730. 53

Domestic Docetaxel-based Combination Chemotherapy in Treatment of Metastatic Breast Cancer

More Information
    Corresponding author:

    ZHANG Jun

  • 摘要: 目的 观察国产多西他赛为主的联合化疗治疗转移性乳腺癌的疗效、毒副反应和临床受益反应(Clinical benefit response,CBR),并以进口多西他赛作对照。方法 A组30例转移性乳腺癌患者,既往未采用蒽环类药物治疗的14例采用国产多西他赛联合阿霉素治疗(A1组),既往蒽环类药物治疗失败的16例采用国产多西他赛联合卡培他滨治疗(A2组);B组25例转移性乳腺癌患者作对照,其中未采用蒽环类药物治疗的11例采用进口多西他赛联合阿霉素治疗(BI组),既往蒽环类药物治疗失败的14例采用进口多西他赛联合卡培他滨治疗(B2组);3周为1个周期,2周期评价疗效,记录毒副反应。结果 A组有效率(CR+PR)66.7%,肿瘤控制率(CR+PR+SD)93.3%。毒副反应主要为骨髓抑制和脱发,可耐受,无治疗相关性死亡。CBR评价有效者73.3%;B组有效率68%,肿瘤控制率92%。毒副反应与A组相似。CBR评价有效者72%。结论 国产多西他赛为主的联合化疗治疗转移性乳腺癌有较好的疗效,毒副反应可耐受,临床受益反应良好,与进口多西他赛的疗效和不良反应相似。

     

    Abstract: Objective  With taxotere as a control, to evaluate the efficacy, toxicity and CBR of domestic docetaxel-based combination chemotherapy in the treatment of metastatic breast cancer. Methods  Fourteen metastatic breast cancer patients without anthracycline2pret reated were t reated with docetaxel and doxorubicin (A1) and sixteen metastatic breast cancer patients with anthracycline-pret reated were treated with docetaxel and capecitabine (A2) . Eleven metastatic breast cancer patients without anthracycline-pret reated were treated with taxotere and doxorubicin (B1) and fourteen metastatic breast cancer patients with anthracycline-pret reated were treated with taxotere and capecitabine (B2) . Every 3 weeks a cycle. Efficacy, toxicity and CBR were recorded in every 2 cycles. Results  Fif ty - five patients were evaluated. The response rate was 66. 7 % and 68 %. The tumor cont rol rate was 93. 3 % and 92 %. The main toxicities were bone marrow suppression and alopecia, and were tolerable. The CBR was 73. 3 % and 72 %. There was no significant difference between treated group and control group. Conclusion  Domestic docetaxel-based combination chemotherapy is effective for metastatic breast cancer. It is well-tolerated and well-clinical benefit responsed.

     

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出版历程
  • 收稿日期:  2006-11-02
  • 修回日期:  2007-04-09
  • 刊出日期:  2007-10-04

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