胃粘膜结肠型化生和小肠型化生对p21、p53、EGFR、PCNA及CEA的联合表达

The Expression of p21、p53、EGFR、PCNA and CEA in Colonic and Small Intestinal Metaplasia of Gastric Mucosa

摘要: 目的　探讨胃粘膜的弱化生与胃癌之间的关系。方法　应用免疫组化S-P法，检测胃粘膜结肠型及小肠型化生细胞中p21、p53、EGFR、PCNA和CEA的表达，并和胃癌组织及正常胃粘膜组织进行对照。结果　p21对判断细胞的癌变倾向有帮助，而p53仅在癌组织内才有明显表达，EGFR在胃癌组有明显表达，结肠型化生与小肠型化生有显著差异，CEA及PCNA在两型肠化生中的表达无显著差异。结论　结肠型化生较小肠型化生更易发生恶性转换。

Abstract: The expression of p21、p53、EGFR、PCNA and CEA in colonic and small intestinal metaplasia of gastric mucosa was observed with immunohistochemical S-P method,and gastriccarcinoma and normal mucosa membrane were compared at the time.The results showed that p53 was only expressed in gastric carcinoma.p21 might be helpful in the assessment of celluar malignance.EGFR was obviously expressed in gastric carcinoma and there was siqnificant difference between in two types of intestinal metaplasia.PCNA and CEA were not significantly different between in two types of intestinal metaplasia.The results suggest:that colonic metaplasia of gastric mucosa taking a turn for malignant is easier than intestinal metaplasia.