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p53和p16蛋白在星形细胞瘤中的表达及其意义

席桂发, 陈坚, 董震, 王代旭, 柯超

席桂发, 陈坚, 董震, 王代旭, 柯超. p53和p16蛋白在星形细胞瘤中的表达及其意义[J]. 肿瘤防治研究, 2004, 31(08): 474-476. DOI: 10.3971/j.issn.1000-8578.3184
引用本文: 席桂发, 陈坚, 董震, 王代旭, 柯超. p53和p16蛋白在星形细胞瘤中的表达及其意义[J]. 肿瘤防治研究, 2004, 31(08): 474-476. DOI: 10.3971/j.issn.1000-8578.3184
XI Gui fa, CHEN Jian, DONG Zhen, WANG Dai xu, KE Chao. Expression and Significance of p53,p16 Protein in Astrocytomas[J]. Cancer Research on Prevention and Treatment, 2004, 31(08): 474-476. DOI: 10.3971/j.issn.1000-8578.3184
Citation: XI Gui fa, CHEN Jian, DONG Zhen, WANG Dai xu, KE Chao. Expression and Significance of p53,p16 Protein in Astrocytomas[J]. Cancer Research on Prevention and Treatment, 2004, 31(08): 474-476. DOI: 10.3971/j.issn.1000-8578.3184

p53和p16蛋白在星形细胞瘤中的表达及其意义

详细信息
    通讯作者:

    席桂发

  • 中图分类号: R730.264

Expression and Significance of p53,p16 Protein in Astrocytomas

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    Corresponding author:

    XI Gui fa

  • 摘要: 目的 研究 p5 3、p16蛋白在星形细胞瘤中的表达及其意义。 方法 应用S P法检测 5 6例星形细胞瘤 p5 3及 p16蛋白, 并同时行组间对照。 结果 p5 3蛋白随肿瘤级别增高表达明显增加, 各级别间差异性显著 (P <0 .0 5 )。而p16蛋白则随级别增高其缺失率增加, 各级别间差异性显著 (P <0 .0 5 )。结论 p5 3蛋白高表达和p16蛋白的缺失是星形细胞瘤发生和恶变的重要原因之一。p5 3表达增高可能是星形细胞瘤恶变的信号, 但 p16在星形细胞瘤的发生和恶性化的过程中可能起更重要的作用

     

    Abstract: Objective To study the expression and significance of p53,p16 protein in astrocytomas. Methods To assess the expression of p53,p16 of 56 astrocytomas with S P method of immunohistochemistry comparing to the placebo and at the same time compare within the group. Results As the rank rising, p53 protein expression increased, comparison between the groups, there are significant difference ( P < 0.05 ),but the deletion of p16 protein increased, comparison between the groups, there are also significant d...

     

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出版历程
  • 收稿日期:  2003-08-28
  • 修回日期:  2004-02-17
  • 刊出日期:  2004-08-04

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