Abstract: Objective This study was conducted to determine the prognostic significance of Nasopharyngeal carcinoma(NPC).Vascular endothelia growth facto (VEGF),C-erbB2、p53 expression in different histological type for 103 cases with NPC prognostic factor affection were discussed. Methods In this retrospective study the authors retrieved clinical data and made lmmunohistochemical preparations on archival tissue from 103 patients with NPC treated with radiation-chemotherapy at the Hubei Medical University additional second hospital between 1986 and 1994,cases was divided into two group,for live and metastatic,and VEGF,C-erbB2 and p53 expression characteristic were detected. Results Out of 103 cases NEGF was associated in live-time,mataststatic with NPC patients,p53 espression was associated in metastatic with NPC (P<0.01 and P<0.05).VEGF,C-erbB2 and p53 expression had't associated with histological type in NPC(P>0.05).The results of this study show that NPC biopsy high VEGF p53 expression,NPC patients metastatic was more than low VEGF and p53. Conclusion s VEGF and p53 expression significance may be useful prognostic factor in NPC.suggest in identifying patients who may benefit from systemic or other novel treatment strategies.