Abstract: Objective To evaluate the efficacy and toxicity of the combination of docetaxel,5-fluorouracil(5-Fu) and calcium folinate(CF) in the treatment of patients with advanced stomach cancer. Methods Group A: The 52 patients with advanced stomach cancer received Docetaxel 75mg/m2 iv,and 5-Fu 500mg/m2 dl～5iv,CF200mg/m2dl～5iv.Cisplatin﹙DDP﹚20mg/m2 dl～5,A cycle is 3 weeks.Group B: 47 patients received EPI 35mg/m2,DDP,CF 250mg/m2and 5-Fu 425mg/m2.A cycle is 1 weeks and 8 cycles is a course of treatment. Results 　The overall response rate of Group A was 59. 6 % and the overall response of the cont rol of Group B was 46. 8 %. The progression f ree median duration of responsive patient s was 7. 8 months in Group A and 6. 0 months in Group B. 1- and 2-year survival rate in Group A was 51 % and 19 %, and in Group B were 47 % and 9 %. There was no obvious difference between overall response rates and 1-year survival rate of two groups ( P > 0. 05) . The progression f ree median duration of responsive patient s and 2-year survival rate were significantly difference between two groups ( P <0. 05) . The major side effect s include phlebitis and peripheral neuritis can be accepted by most of the patient s. Conclusion 　Combination of Docetaxel, CF and 5-Fu is an effective regimen in the t reatment of patient s with advanced stomach cancer.