Abstract: Objective 　To study the expression of EGFR (epidermal growth factor receptor), E-cadherin and their correlation in colorectal cancer. Methods 　45 cases of colorectal cancer were collected . The expression of EGFR and E-cadherin was tested using immunohistochemical staining, and the expression features were analyzed. Results 　In the colorectal cancer tissue, EGFR expression was related to the invasion depth ( P < 0. 05) and Duke's stage ( P < 0. 05), and the expression of E2cadherin was related to the invasion depth ( P < 0. 01), Duke's stage ( P < 0. 05) and the degree of differentiation ( P < 0. 01) . EGFR expression was negatively related to E-cadherin expression ( rs = - 0. 6466, P < 0. 01) . Conclusion 　The expression of EGFR and E-cadherin was related to the clinical pathologic factors, which may be regarded as a prognostic marker of colorectal cancer. The decrease of E-cadherin expression may be related to the increase of EGFR expression.