直肠间叶性肿瘤的光镜及免疫组化观察

The Mesenchymal Tumors of Rectum were Investigated by Light Microscopy and Immunohistochemisty

摘要: 目的　探讨直肠间叶性梭形细胞肿瘤的诊断与鉴别诊断和预后指标。方法　在光镜观察的基础上, 运用免疫组化方法检测 1 5例直肠间叶性梭形细胞肿瘤的 Vimentin、Actin、Desmin、S- 1 0 0蛋白和 CD34的表达。结果　病理学确诊良性 2例, 恶性 1 3例, 肿瘤平均直径 6.8cm,平均核分裂数 8个 /1 0 HPF,并随、分级增高而增多 ;免疫组化染色证实为平滑肌肿瘤 1 1例 (良性2例, 恶性 9例 ), GIST 4例 ;随访 1 3例恶性肿瘤中有 3例复发, 6例死亡, 均为、级, 其平均核分裂数 1 2个 /1 0 HPF。结论　肿瘤大小、核分裂数为直肠平滑肌肿瘤和 GIST良恶性诊断的重要指标 ;免疫组化染色有助于两者的鉴别诊断 ;瘤细胞异型性、核分裂多少与其预后有关。

Abstract: Objective To explore the diagnostic and prognostic criteria of mesenchymal spindle cell tumor of rectum. Methods In addition to light microscopic observations,the expression of Vimentin,Actin,Desmin,S-100 and CD34 were detected by immunohisto-chemical stain in 15 cases of mesenchymal spindle cell tumor of rectum. Results Out of 15 cases tumors,2 cases were benign tumors and 13 cases were malignant tumors.The average diameter of tumors was 6.8cm.The average mitotic count was 8/10HPF,and it increased with gra...