卵巢癌合并腹水的治疗

Treatment of Ovarian Carcinoma Complicated with Ascites

摘要: 目的　探讨卵巢癌腹水的综合治疗方法。方法　 72例均经腹腔穿刺排净腹水。 71例细胞学查到癌细胞的腹腔注入化疗药物。分 3组 :顺铂组 (DDP) 1 8例, 80～ 1 0 0 mg/次 ;卡铂组(CBP) 48例, CBP40 0～ 50 0 mg/次 ;DDP+CBP组 5例, DDP或 CBP交换应用。配合静脉联合化疗1～ 2个疗程后手术切除肿瘤。术后再配合腹腔及静脉化疗。一般腺癌、性索间质肿瘤选用 VCP、CAP或 EAP方案, 生殖细胞肿瘤选用 VCA或 EBP方案。一年内给予规范性化疗 8～ 1 2个疗程。结果　腹腔化疗消除腹水 CBP组较 DDP组满意 (P<0 .0 5)。总的腹水完全控制率为 80 .3%, 肿瘤完全切除率为 59.2 %。结论　卵巢癌合并腹水需采用包括化疗及手术在内的综合治疗。

Abstract: Objective To investigate combined therapy method of ovarian carcinoma complicated with ascites. Methods 72 patients were performed abdominocentesis and aspirated Ascites completely.Intraperitoneal(IP)chemotherapy was given for positive ascitic cytology of 71 patients.They were divided into three groups:18 case were treated by IP of DDP(80~100mg/body);48 by IP of carboplatin (CBP,400~500mg/body);and 5 by IP of DDP and CBP alternately.IP and intravenous(IV) chemotherapy 1~2 therapeutic courses followed by ope...