表阿霉素、顺铂、氟脲嘧啶联合治疗有颈淋巴结转移鼻咽癌的近期疗效分析
Evaluation of lymph node response to neoadjuvant chemotherapy in untreated nasopharyngeal carcinoma
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摘要: 目的 评价表阿霉素、顺铂、氟脲嘧啶三药联合治疗有颈淋巴结转移鼻咽癌的近期疗效及毒性。方法 1999.10～ 2 0 0 1.8对 2 6例有颈淋巴结转移的鼻咽癌患者在放疗前用表阿霉素 (70mg/m2, d1)加顺铂 (10 0mg/m2, d1)和 5 -氟脲嘧啶 (10 0 0mg/m2, d1～ 5 )方案联合化疗, 2 1天为一周期, 共 2周期。结果 1.疗效 :化疗后颈淋巴结完全消失 (CR) 8例 (30 .77% ), 缩小 >5 0 % (PR) 14例 (5 3.85 % ) ;鼻咽部病灶CR0例, PR17例 ;有效率 (PR +CR) :颈淋巴结为 84 .6 2 %, 鼻咽部原发灶为 6 5 .38% ;放射治疗结束时颈转移淋巴结全部消失, 鼻咽部原发病灶消失 19例, 另 7例缩小大于 5 0 %, 且病灶表面黏膜均恢复光滑。 2 .毒副反应 :①血液学毒性 :WBC减少 3+4级为 14例 (5 3.8% )、2 6周期 (5 0 % ) ;PLT减少 3+4级4例、6周期。②非血液学毒性 :由于本组资料在化疗前后均应用 5 HT拮抗剂预防恶心呕吐, 消化道反应无法评价 ;...Abstract: Objective To evaluate the response and toxicity of neoadjuvant chemotherapy (Epirubicin plus DDP and 5-Fu) in patients with of nasopharynx carcinoma (NPC). Methods From April 1999 to August 2001, twenty-six patients with NPC (N 2 17, N 3 9; T 2 8,T 3 12,T 4 6 cases and no M 1) were treated with neoadjuvant chemotherapy consisting DDP (100mg/m 2 i.v. on Day 1), epirubicin (70 mg/m 2 i.v. on Day 1), and 5-Fu(1000mg/m 2 i.v. from day 1 to day 5), this regimen was repeated every 21 days. All patient...
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