全雄激素阻断治疗晚期前列腺癌
Observation of maximal androgen blockade in treatment of advanced prostate cancer
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摘要: 目的 观察诺雷德 (Zoladex)和氟他胺 (Flutamide)治疗晚期前列腺癌的临床疗效, 分析影响疗效的有关因素。方法 对 1998年 3月～ 2 0 0 1年 3月收治的 2 3例晚期前列腺癌, 给予以诺雷德和氟他胺为主治疗, 并对其疼痛缓解程度、身体功能状况、肿瘤消退情况及血象、肝肾功能等进行观察分析。结果2 3例中完全缓解 (CR) 5例, 部分缓解 (PR) 8例, 好转 (MR) 7例, 缓解率 5 6 .5 %, 有效率 86 .9%。治疗后有 18例身体功能状况改善, KPS≥ 5 0分, 占 78.2 %, 除乳房胀痛外, 无明显不良反应。临床治疗效果与患者身体功能状况、既往治疗、转移部位及PSA改变等因素有关。结论 全雄激素阻断治疗晚期前列腺癌, 疗效肯定, 不良反应轻微, 对初治和睾丸切除术后复发的前列腺癌均有治疗作用, 初治较复治效果好。Abstract: Objective To observe the clinical effect of advanced prostate cancer treated by Zoladex and Flutamide, and analyze the related factors influencing curative effect. Methods 23 cases of advanced prostate cancer in 1998～2001 were treated with Zoladex and Flutamide, and their pain,KPS, tomour shrink, blood routine, renal and hepatic function were analyzed. Results In 23 patients, CR 5 cases, PR 8 cases, MR 7 cases. Quality of life improved,and KPS≥50 in 78.2%. Conclusion Maximal androgen blockad...
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