整合素α_5β_1和nm23在乳腺癌中的表达及临床意义

Expression of integrin α_5β_1 and nm23 in breast cancer and their clinical significance

摘要: 目的　研究整合素α5β1及nm2 3在乳腺癌中的表达及临床意义, 以及两者之间的相关性。方法采用免疫组织化学S -P法, 检测 5 1例乳腺癌和 10例正常乳腺组织的整合素α5β1及nm2 3的表达情况。结果　①乳腺癌中整合素α5β1的低表达与淋巴结转移阳性、组织分化低密切相关 ;②乳腺癌中nm2 3的低表达与淋巴结转移阳性密切相关 ;③乳腺癌中整合素α5β1的表达水平与nm2 3的表达水平呈正相关。结论　整合素α5β1和 /或nm2 3的低表达可作为早期识别具有高浸润和转移潜能的乳腺癌并判断其预后的有用指标。

Abstract: Objective To investigate the expression of integrin α 5β 1 and nm23 and their clinical significance in breast cancer and the correlation between them. Methods Expression of integrin α 5β 1 and nm23 was examined immunohistochemically in 51 cases of breast cancer and 10 cases of normal breast tissues. Results ① The low expression of integrin α 5β 1 in breast cancer tissues is associated with the metastasis of lymph nodes and the tissues low differentiation. ② The low expression of nm23 in breast canc...