星形细胞肿瘤VEGF、MVD和Ki-67表达的临床意义
Clinical implications of VEGF and Ki-67 expression in astrocytic tumor patients
-
摘要: 目的 探讨VEGF和Ki- 6 7表达与星形细胞肿瘤恶性程度、微血管密度 (MVD)、瘤细胞增殖以及病人预后等方面的关系, 评估两者在病理诊断和临床治疗中潜在的应用价值。方法 采用免疫组化S -P法, 分析 4 8例脑星形细胞肿瘤标本中VEGF蛋白和Ki- 6 7的表达, 并用FⅧ -RA标记血管内皮细胞以计算MVD。结果 VEGF阳性率在低、高度恶性星形细胞肿瘤中分别为 2 6 .0 9%、6 4 .0 0 % ;在低度恶性星形细胞肿瘤中Ki- 6 7LI和MVD分别为 8.89± 5 .80和 6 .6 9± 4 .81,但在高度恶性肿瘤中分别为 17.4 9± 13.13和 2 3.6 2± 6 .78,其差异具有显著性 ;术后生存两年以上者, VEGF表达、MVD和Ki- 6 7LI明显低于术后生存两年以下者 ;相关分析表明VEGF蛋白表达、MVD与Ki- 6 7LI间存在相关性。结论 VEGF可促进肿瘤血管形成和恶性进展, 对病人的预后产生影响 ;同时定量检测MVD和Ki- 6 7,对星形细胞肿瘤病理分级和预后判断有一定帮助。Abstract: Objective To evaluate the relationship of VEGF and Ki-67 expression with the pathologic grades, microvessels density, and the prognosis in patients with astrocytic tumors. Methods 48 astrocytic tumor tissues were investigated for VEGF, Ki-67 and FⅧ-RA using S-P immunohistochemical staining. Results There was significant difference of the VEGF expression level between low and high grades astrocytic tumors, in which the positive rate were 26.09% and 64.00% respectively. In high grades (Ⅲ|Ⅳ) astrocyti...
下载:
