MK和CD105在大肠癌中的表达及其临床意义

Expression of Midkine and CD105 in Colorectal Carcinoma and Its Clinical Significance

摘要: 目的探讨MK和CD105的表达与大肠癌生物学行为的关系及对预后的意义。方法采用免疫组织化学方法检测50例大肠癌组织MK和CD105表达水平,并对其与大肠癌临床病理特征的关系进行统计学分析。结果本组50例中,MK阳性表达率为72%。MK为阳性时CD105标记的MVD值(71.73±6.99)明显高于MK为阴性组的MVD值(66.09±7.49)(P<0.05)。两者的表达均与大肠癌的Duke's分期、淋巴结转移、浸润深度有关。结论MK的阳性表达与大肠癌的发生、发展和预后密切相关,可联合CD105作为一组有价值的肿瘤标记和预后指标。

Abstract: Objective To investigate the relationship between the expression of midkine(MK) and CD105 in colorectal carcinoma and the biological behavior and prognosis of colorectal carcinoma. Methods The expression of midkine(MK) and CD105 were detected by immunohistochemical technique in 50 colorectal carcinoma specimens. The relationship of their expression to clinicopathological characteristics was statistically analyzed. Results Of the 50 cases, the positive expression of MK was 36 cases(72%). When MK expression w...