Abstract: Objective 　Using hepatocarcinoma model of rabbit s based on liver cirrhosis and injected VX2 cells to observe changes of pathological morphology af ter irradiation under state of liver disease. Methods 　Sixteen rabbit s with liver cirrhosis and hepatocarcinoma (experimental group one), and those were randomly divided into two groups ( n = 8) . Eight rabbit s with hepatocarcinoma (experimental group two), and those were also randomly divided into two groups ( n = 4) . The stereotactic irradiation with sin2 gle dose of 20 or 30 Gy was respectively performed on each experimental group. Rabit s of experimental groups were both killed af ter irradiation for three weeks. The liver pathological morphological changes in the experimental groups one and two were observed by pathological routine examination before and af ter irradiation. Reticular fiber and Masson's t richrome stainings were performed to analyze and identify the difference of liver fibrosis between the two groups before and after irradiation. Results 　Massive necrosis of tumor tissues were observed and mesenchymal fibrous tissues were swelled and partial disrupted in ex2 perimental groups. In experimental group one, obvious necrosis of hepatocytes was seen around the tumor tissues, with slightly segmentation. In experimental group two, most of hepatocytes around the tumor tis2 sues were degenerated, and there were no marked changes in fibrous tissue in experimental groups through observation of reticular fiber and Masson stain before and af ter irradiation. Conclusion 　The liver tolerance obviously depress af ter irradiation for hepatocarcinoma based on liver cirrhosis.