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罗洪波, 刘修恒, 陈智敏, 张德玲. 肾细胞癌COX-2 及MMP-2 的免疫组化研究[J]. 肿瘤防治研究, 2005, 32(06): 354-346. DOI: 10.3971/j.issn.1000-8578.2783
引用本文: 罗洪波, 刘修恒, 陈智敏, 张德玲. 肾细胞癌COX-2 及MMP-2 的免疫组化研究[J]. 肿瘤防治研究, 2005, 32(06): 354-346. DOI: 10.3971/j.issn.1000-8578.2783
LUO Hong-bo, LIU Xiu-heng, CHEN Zhimin, ZHANG De-Ling. Immunohistochemical Study of COX-2 and MMP-2 in Human Renal Cell Carcinoma[J]. Cancer Research on Prevention and Treatment, 2005, 32(06): 354-346. DOI: 10.3971/j.issn.1000-8578.2783
Citation: LUO Hong-bo, LIU Xiu-heng, CHEN Zhimin, ZHANG De-Ling. Immunohistochemical Study of COX-2 and MMP-2 in Human Renal Cell Carcinoma[J]. Cancer Research on Prevention and Treatment, 2005, 32(06): 354-346. DOI: 10.3971/j.issn.1000-8578.2783

肾细胞癌COX-2 及MMP-2 的免疫组化研究

Immunohistochemical Study of COX-2 and MMP-2 in Human Renal Cell Carcinoma

  • 摘要: 目的 探讨COX-2在肾癌组织中的表达及其与肿瘤侵袭转移的关系。方法 采用SP法检测45例肾细胞癌中COX-2和MMP-2的表达情况。结果 COX-2主要为癌组织的表达,而在癌旁正常组织中无表达或弱表达,COX-2高表达与肿瘤分级、分期和分型有统计学差异(P<0.01);MMP-2在正常肾组织均为阴性,肾癌组织中的表达与肿瘤的分级及分型有统计学差异(P<0.01),而与分期则无统计学差异(P>0.05);COX-2与MMP-2阳性表达率无统计学差异(P=1.000),且两者的吻合度较强(κ=0.867)。结论 肾癌中COX-2的高表达与肾癌的分级、分期、分型及肿瘤侵袭转移有关,提示COX-2选择性抑制剂是防治肾癌的可行途径之一。

     

    Abstract: Objective  To study the expression of COX-2 in human renal cell carcinoma (hRCC) and it s relation to invasion and metastasis of RCC. Methods  The expression of COX-2 and MMP-2 in primary RCCs specimens were detected by immunohistochemical technique. Results  There was no or weak expression in non-carcinomatous speciment s of renal. Overexpression of COX-2 in renal cell carcinomas was related to it s pathologic grading, clinical staging and histological type ( P < 0. 01 ) ; The expression of MMP-2 in normal renal tissue was negative. The expression of MMP-2 was related to the pathologic grading and histological type ( P < 0. 01), But the expression of MMP-2 was not related to clinical staging ( P > 0. 05) . The correlation was found between COX-2 and MMP-2. Conclusion  The overexpression of COX-2 in renal cell carcinoma may play a crucial role in its pathologic grading, clinical staging, histological type, invasion and metastasis in renal cell carcinoma, indicating that COX-2 may provide a target for chemotherapy strategy for renal cell carcinoma.

     

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