Abstract: Objective To investigate the expression and clinical significance of Ang-2 and VEGF in human breast carcinoma. Methods The expression of Ang-2 and VEGF in 85 specimens of breast carcinoma and in 42 specimens of fibroadenoma of breast was examined by SABC immunohistochemical method,and the relationship between these two factors and the clinicopathological factors was evaluated. Results The positive rate of Ang-2 in breast carcinoma(68.24%,58/85) was significantly higher than that in fibroadenoma of breast(7.14%, 3/ 42 ) ( P < 0. 0001 ), and the positive rate of VEGF in breast carcinoma (57. 65 %, 49/ 85) was significantly higher than that in fibroadenoma of breast ( 4. 76 %, 2/ 42 ) ( P <0. 0001), too. The expression of Ang22 and VEGF were not associated with patient age and tumor size ( P > 0. 05) . The positive rate of VEGF in group of stage Ⅲand Ⅳ and lymph node2positive were significantly higher than that in group of stage Ⅰand Ⅱ and lymph node2negative respectively ( P < 0. 0001) . The positive rate of Ang22 in group of stage Ⅲand Ⅳwas significantly higher than that in group of stage Ⅰand Ⅱ ( P = 0. 015) . The positive rate of Ang22 in group of lymph node2positive was significantly higher than that in group of lymph node2negative ( P < 0. 0001) . There was a significantly correlation between the expression of Ang22 and VEGF. Conclusion 　There was an abnormal expression of Ang22 and VEGF in breast carcinoma, these two factors were associated with the prognosis of patient s.