DDP和沙培林胸腔用药联合NP方案对肺癌合并恶性胸腔积液近远期疗效的观察
Clinical observation of combination chemotherapy and intrapleural injection of Sapylin and Cisplatin on malignant pleural effusions
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摘要: 目的 观察DDP和沙培林胸腔用药联合NP方案全身化疗治疗肺癌合并恶性胸腔积液的近远期疗效。方法 32例肺癌合并恶性胸腔积液患者随机分成两组, A组 :1 6例, 胸膜腔内单用药组, 使用DDP和沙培林, B组 :1 6例, 胸膜腔内用药并联合使用NP(NVB +DDP)方案全身化疗。结果 ①A、B两组胸水控制短期有效率分别为 75 %和 87.5 %, 总有效率为 81 .3%, 两组比较无显著性差异 (P >0 .0 5 )。②A组1年、2年生存率分别为 4 3.75 %和 6 .2 5 %, B组分别为 6 2 .5 %和 31 .2 5 %, 两组比较有显著性差异 (P <0 .0 5 )。结论 DDP和沙培林胸腔用药能有效控制胸水 ;在胸腔用药的基础上继用NP方案全身化疗有助于提高肺癌合并恶性胸腔积液患者的生存率Abstract: Objective To study the curative effect of intrapleural injection of Sapylin and Cisplatin in combination with NP regimen adjuvant chemotherapy. Methods 32 patients were divided into two Groups:16 patients were treated with intrapleural injection of Sapylin and Cisplatin(A gronp),16 patients were treated with intrapleural injection of the same drugs in combination with NP regimen adjuvant chemotherapy(NVB+DDP)(B group). Results ① The short term effective rates of A and B group were 75% and 87.5% resp...
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