Abstract: Objective 　To observe the antitumor effect and toxicities of MINE regimen based on mitoxantron, etoposide, ifosfamide in the patients with recurrent and ref ractory non-Hodgkin's lymphoma. Methods 　Total of 23 patient s failing to respond to CHOP regimen were t reated with MINE regimen and every patient had gotten at least 2 cycles t reatment . MIT 6～8mg/ m2 / d, IV on d1 ; IFO 2. 0 IV on d1～3, combined with mesna 400mg IV for 3 times (0h、4h、8h), d1～3 ;VP16 80mg/ m2 / d, IV on d1～3 。The therapeutic effect s and toxicity were evaluated according to the WHO criteria. Results 　In 23 patient s, 65. 2 % of response rate were achieved with 5 case CR, 10 case PR, 3 case SD, 5 case PD. Main side-effect was myelosuppression. Neutropenia was reported in 73. 9 % of patient s and it was mostly Grade Ⅰ/ Ⅱ. All of them got G-CSF treatment and the counts of white blood cells became normal. No patient died of toxicity related to chemotherapy. Conclusion 　MINE regimen has a safe and higher therapeutic effect on resistant patient s with NHL.