Abstract: Objective To investigate the effect of CDX2 protein in the carcinogenesis, progression, invasion and metastasis of human colorectal adenocarcinomas and identify its relation to the clinicopathological indices of colorectal adenocarcinoma. Methods CDX2 protein was detected by SP-immunohistochemistry in tissues. Results The expression of CDX2 protein distributed in the karyon. From colorectal adenomas to colorectal adenocarcinomas,and from well differentiated colorectal adenocarcinomas to the poorly different...