Abstract: Objectives 　To evaluate the therapeutic outcome and radioactive toxicity of locoregionally advanced oropharyngeal carcinoma t reated by different approaches. Methods 　A ret rospective study was done on 192 patient s by three different ways of radiotherapy. 63 patient s received conventional f ractionated radiotherapy (CF) alone ; 65 patient s received split-course accelerated hyperf ractionated radiotherapy (S-A HF) ; 64 patient s received the combination t reatment (CMT) which consisted of conventional fractionated radiotherapy and concomitant chemotherapy . Results 　The 1, 3, 5-year overall survival rates were 65. 1 %, 37. 5 %, 33. 9 % and disease2f ree survival rates were 43. 2 %, 31. 3 %, 28. 6 %, respectively . The 1, 3, 52year overall survival rates were found no significant difference among these three groups ( P =0. 129) . The 1, 3, 52year disease-free survival rates had significant difference among three group s ( P =0. 022) . The incidences of grade 3 + acute muscositis in three groups were 14. 7 %, 40. 3 % and 44 %, respectively. Conclusion 　The combination of sinulliceous chemotherapy and radiotherapy would improve the disease-free survival rate and not increase overall survival rate in locoregionally advanced oropharyn-geal carcinoma . Therefore it improved the incidence of acute local morbidity.