Abstract: Objective 　To analyze the result of treatment with alone radiotherapy(R) and radiotherapy plus chemotherapy ( R + C ) and investigate it s prognostic factors for brain metastasis ret rospectively. Methods 　From August 1992 to July 2004 46 patients of brain metastasis were studied in 2 groups.Group R with 28 cases, whole brain irradiation were given with the dose 30～36 Gy first, then shrink the field and increase the dose to 40-60 Gy . Group R + C with 18 cases, give whole brain irradiation with the dose 30 Gy first, then reduce the field, in the same time, use the VM-26 100mg + N. S 500ml for iv drop, qd for 3 days, and the Me-CCNU 150mg～200mg for oral on the fourth days, 6～8 week as circle, repeat for 3～6 circles, the totle dose of irradiation was still 40～60 Gy. Results 　The survival rate and local control rate of over 12 months in group R + C was better than group R ( P < 0. 05) . The relation with efficacy and extercranium metastasis, primary tumor is cont rolled or no and it s pathological type was obvious . Conclusion 　The R + C is superior to R in the prolong survival period and local cont rol rate in treatemt for the brain metastasis. The relation with efficacy and extercranium metastasis, primary tumor is cont rolled or no and it =s pathological type is significant prognostic factor for efficacy. If stereotactic radiosurgery combined with whole brain irradiation the result shall be best .