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饮酒增加广西乙醛脱氢酶2 基因变异基因型携带者发生肝癌的危险性

叶新平, 彭 涛, 苏智雄, 肖开银, 尚丽明, 黎乐群

叶新平, 彭 涛, 苏智雄, 肖开银, 尚丽明, 黎乐群. 饮酒增加广西乙醛脱氢酶2 基因变异基因型携带者发生肝癌的危险性[J]. 肿瘤防治研究, 2007, 34(10): 793-795. DOI: 10.3971/j.issn.1000-8578.2392
引用本文: 叶新平, 彭 涛, 苏智雄, 肖开银, 尚丽明, 黎乐群. 饮酒增加广西乙醛脱氢酶2 基因变异基因型携带者发生肝癌的危险性[J]. 肿瘤防治研究, 2007, 34(10): 793-795. DOI: 10.3971/j.issn.1000-8578.2392
YE Xin-ping, PENG Tao, SU Zhi-xiong, XIAO Kai-yin, SHANG Li-ming, LI Le-qun. Alcohol Consumption Increases Risk for Hepatocellular Carcinoma Among Guangxi Residents Carrying Mutant Aldehyde Dehydrogenase-2 Genotypes[J]. Cancer Research on Prevention and Treatment, 2007, 34(10): 793-795. DOI: 10.3971/j.issn.1000-8578.2392
Citation: YE Xin-ping, PENG Tao, SU Zhi-xiong, XIAO Kai-yin, SHANG Li-ming, LI Le-qun. Alcohol Consumption Increases Risk for Hepatocellular Carcinoma Among Guangxi Residents Carrying Mutant Aldehyde Dehydrogenase-2 Genotypes[J]. Cancer Research on Prevention and Treatment, 2007, 34(10): 793-795. DOI: 10.3971/j.issn.1000-8578.2392

饮酒增加广西乙醛脱氢酶2 基因变异基因型携带者发生肝癌的危险性

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    通讯作者:

    黎乐群

  • 中图分类号: R735. 7 ;R73231

Alcohol Consumption Increases Risk for Hepatocellular Carcinoma Among Guangxi Residents Carrying Mutant Aldehyde Dehydrogenase-2 Genotypes

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    Corresponding author:

    LI Le-qun

  • 摘要: 目的 研究乙醛脱氢酶2(ALDH2)基因多态性与饮酒因素交互作用在广西原发性肝癌发生中的作用。方法 对广西壮族自治区300例肝癌患者和292例正常对照人群进行流行病学调查研究,并用PCR-RFLP方法检测ALDH2基因型。结果 肝癌组和对照组中ALDH2变异基因型携带者分别占50.33%和47.95%(P=0.561)。肝癌人群ALDH2基因型不存在区域和民族差异(P〉0.05)。饮酒频度每周≥3次的ALDH22携带者发生肝癌的危险性是饮酒频度每周〈3次的ALDH2*1携带者的3、34倍(95%CI1.75~6.41)。HBsAg阳性者发生肝癌的危险性明显高于HbsAg阴性者(P〈0.001)。结论 ALDH2基因型不构成壮汉族间肝癌发病差异的基础,频繁饮酒可能是ALDH2基因变异基因型携带者发生肝癌的危险因素。

     

    Abstract: Objective  To study the relationship between aldehyde dehydrogenase-2 (ALDH2) gene polymorphism and the susceptibility of hepatocellular carcinoma ( HCC) . Methods  Three hundred cases of HCC and 292 controls were genotyped for the ALDH2 polymorphisms by using polymerase chain reaction-rest riction fragment length polymorphism ( PCR-RFL P) method. Results  The f requencies of ALDH2 variant genotype (ALDH2 1*2/ ALDH22) in cases and cont rols was 50. 33 % and 47. 95 % respectively ( P = 0. 561) . There was no significant difference of ALDH2 genotype among Zhuang and Han groups in cases ( P > 0. 05) . The risk for liver cancer was 3. 34 times higher in alcoholics ( ≥3 times drinking per week) with ALDH2 * 2 genotype than cases carrying ALDH2 * 1 genotype while drinking less than 3 times per week (95 %CI 1. 75~6. 41) . The positive rates of HBsAg between cases and controls showed differences, much higher in cases (84. 67 %) than those in controls (10. 27 %) . Conclusion  The genotype aldehyde dehydrogenase-2 in different ethnicity may not influence the risk of HCC. Frequently alcoholic consumption and HBV infection might increase risk for HCC among Guangxi residents carrying mutant ALDH2 genotypes.

     

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出版历程
  • 收稿日期:  2006-10-15
  • 修回日期:  2007-03-04
  • 刊出日期:  2007-10-04

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