Abstract: Objective 　To compare the response rate and the side effects of the regimen NPR (NVB + DDP+ radiotherapy) with the regimen FLPR ( FLP (5-Fu/ CF + DDP) + radiotherapy) in the treatment of eophagus. Methods 　A total of 63 cases with esophagus entered this trial. The patient s were randomly divided into two groups, group A with 31 cases and group B with 32 cases. The patient s in group A received the NPR regimen ( i. e. NP therapy for two cycles and then palliative radiotherapy with about 6500cGy), and the patients in group B received the FLPR regimen ( FLP therapy for two cycles and then palliative radiotherapy with about 6500cGy) . Results 　①The total response rate of the NPR regimen was 83. 9 %, the median survival time (MST) was 14. 7 months, the one-year survival rate ( YSR) was 76. 0 %, but the total response rate of FLPR regimen was 71. 9 %, MST was 12. 3 months, YSR 69. 0 %, and there was no significant difference between these two regimens ( P > 0. 05) ; ②The main side effect of these two regimens was bone marrow depression, and the grade Ⅲ～ Ⅳ leucopenia was 16. 1 % in group A, and 6. 3 % in group B ( P > 0. 05) . Conclusion 　The total response rate and the one-year survival rate of the NPR regimen were higher than the FLPR regimen. Although there was no significant difference between these two regimens, the patient s treated with the NPR regimens has higher CR rate compared with the FL PR regimen, and can tolerate the poisonous and side effects.