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卵圆细胞的生物学特征及其与肝癌发生的关系

陈琼荣, 向景, 刘清波, 赵国强, 车丽洪

陈琼荣, 向景, 刘清波, 赵国强, 车丽洪. 卵圆细胞的生物学特征及其与肝癌发生的关系[J]. 肿瘤防治研究, 2008, 35(06): 390-393. DOI: 10.3971/j.issn.1000-8578.2337
引用本文: 陈琼荣, 向景, 刘清波, 赵国强, 车丽洪. 卵圆细胞的生物学特征及其与肝癌发生的关系[J]. 肿瘤防治研究, 2008, 35(06): 390-393. DOI: 10.3971/j.issn.1000-8578.2337
CHEN Qiong-rong, XIANG Jing, LIU Qing-bo, ZHAO Guo-qiang, CHE Li-hong. Molecular Biologic Characteristics and Relationship with Hepatocarcinogenesis of Oval Cells[J]. Cancer Research on Prevention and Treatment, 2008, 35(06): 390-393. DOI: 10.3971/j.issn.1000-8578.2337
Citation: CHEN Qiong-rong, XIANG Jing, LIU Qing-bo, ZHAO Guo-qiang, CHE Li-hong. Molecular Biologic Characteristics and Relationship with Hepatocarcinogenesis of Oval Cells[J]. Cancer Research on Prevention and Treatment, 2008, 35(06): 390-393. DOI: 10.3971/j.issn.1000-8578.2337

卵圆细胞的生物学特征及其与肝癌发生的关系

详细信息
    通讯作者:

    赵国强

  • 中图分类号: R735. 7

Molecular Biologic Characteristics and Relationship with Hepatocarcinogenesis of Oval Cells

More Information
    Corresponding author:

    ZHAO Guo-qiang: ZHAO Guo2qiang3

  • 摘要: 目的通过动态的方法观察卵圆细胞的主要生物学特征及其在肝癌发生过程中的演变规律,揭示卵圆细胞与肝癌发生之间的关系。方法构建实验性肝癌的大鼠诱癌模型,运用常规HE染色、免疫组织化学和爱新蓝染色等方法,动态观察卵圆细胞在肝癌发生过程中的演变规律和分子表达特征。结果随着诱癌时间延长,逐渐出现卵圆细胞的增生、癌前病变、胆管细胞癌和(或)肝细胞癌,各阶段卵圆细胞均表达OV-6、AFP和c-kit。结论原发性肝癌可能与卵圆细胞异常分化有关,卵圆细胞特征性表达为OV-6、AFP和c-kit。

     

    Abstract: Objective  To detect the major biologic characteristics of oval cells, and to explore it s correla2 tion to hepatocarcinoma through dynamic observation on evolutive law of the oval cells in experimental hepatocarcinogenesis. Methods  By const ructing the experimental liver cancer models and using tech2 niques including routine HE stain, alcian blue stain and immunohistochemist ry to observe the major bio2 logic characteristics of the oval cells and the law of evolution in hepatocarcinogenesis. Results  Along with the prolonging of cancer2induction, the oval cells proliferated gradually, then come forth precancer2 ous lesions, and became hepatocellular and (or) cholangiocellular carcinoma. OV26, AFP and c2kit were expressed in all oval cells in every period. Conclusion  Associated with abnormal differentiation of oval cells maybe associated with primary liver cancer, and the oval cells express OV26, AFP and c2kit charac2 teristically.

     

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出版历程
  • 收稿日期:  2007-10-31
  • 修回日期:  2008-02-27
  • 刊出日期:  2008-06-04

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