微血管密度在直肠癌切除中的意义

涂小煌; 王为忠; 王烈; 黎成金; 宋京翔; 宋丽娜; 赵春雷

doi:10.3971/j.issn.1000-8578.2329

微血管密度在直肠癌切除中的意义

南京军区福州总医院普通外科研究所; 第四军医大学附属西京医院胃肠外科

详细信息

中图分类号: R735. 3 + 7
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出版历程
- 收稿日期: 2007-08-19
- 修回日期: 2007-11-12
- 刊出日期: 2008-06-04

Significance of Micro-vessel Density in Resection of Rectal Cancer

1.Institute of General Surgery in Nanjing Military Command Fuzhou General Hospital; Fuzhou 350025; China; 2.Department of Gastroenteric Surgery; Xijing Hospital; Fourth Military Medical University

摘要

摘要: 目的研究直肠癌组织及其远侧端黏膜组织中微血管的分布,并从分子病理学水平上探讨直肠癌的安全远侧切缘。方法采用免疫组织化学染色半定量测定方法对45例直肠癌及其远侧端黏膜的微血管密度(Micro-vessel Density,MVD)进行研究。结果直肠癌肿瘤组织中MVD较高;直肠癌远侧端黏膜MVD随着距离增大而降低,且在直肠远侧端1.0cm内有显著性异常改变;直肠远侧端黏膜MVD与肿瘤分期以及病理类型无关。结论直肠腺癌远侧端MVD可作为直肠远切端切除长度的一个相对独立的分子病理学指标,直肠远侧端切除的长度至少应大于1cm。
- 直肠癌 /
- 全直肠系膜切除术 /
- 微血管密度 /
- PET/CT
Abstract: Objective 　To study micro2vessel dist ribution in rectal cancer and it s distal mucosa and to ex2 plore the required distal margin of radical surgery for rectal cancer in molecular pathologic level. Methods 　MVD (Micro2vessel Density) in rectal cancer and rectal distal tissue portion were detected by immuno2 histochemical stain and semi2determination techniques. Results 　MVD in rectal cancer was significantly higher than that in distal mucosa to cancer margin. MVD was decreased in distal mucosa along the anal direction. But only in less than 1. 0cm distal rectal tissue was significantly abnormal. Conclusion 　MVD in distal mucosa to cancer margin might be a relatively independent parameter to predict resection margin. From molecular pathology point of view, the length of distal resection margin to rectal cancer should be longer than 1. 0 cm.
- Rectal cancer /
- Total mesorectal excision /
- Micro-vessel density /
- PET/CT