大分割三维适形放疗联合低剂量密集式化疗治疗III期非小细胞肺癌72例临床分析
Three Dimensional Conformal Hypofractionated High Dose Radiotherapy Combined with Low Dose Density Chemotherapeutic Regimen for 72 Cases of Stage III Non-small Cell Lung Cancer
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摘要: 目的研究大分割三维适形放疗联合低剂量密集式化疗治疗临床III期非小细胞肺癌的疗效及毒副反应。方法72例Ⅲ期NSCLC患者均采用大分割三维适形放射治疗,单次治疗剂量为400cGy,治疗次数为14次,总剂量为56Gy,18~21d完成;同期采用低剂量密集式TP方案化疗,化疗疗程为4~6周期。结果72例患者获得完全随访。肺原发灶总有效率为93.1%;纵隔转移淋巴结总有效率为100.0%。肺鳞癌总有效率为93.5%;肺腺癌总有效率为81.1%。全组患者1、2年局控率分别为63.9%和41.7%;中位生存时间为18.9个月,1、2年生存率分别为76.2%和47.2%。白细胞下降总发生率为95.8%;恶心、呕吐反应为33.3%;I、II级急性放射性食管炎和放射性肺炎发生率分别为54.2%和12.5%。结论大分割三维适形放疗联合低剂量密集式化疗治疗III期非小细胞肺癌有较好的近期疗效,毒副作用可耐受,远期疗效待观察。Abstract: Objective To evaluate the efficacy and toxicity of three dimensional conformal hypo fractionated high dose radiotherapy combined with concurrent low dose density chemotherapeutic regimen for Stage III nonsmall cell lung cancer. Methods 72 cases patients with NSCLC were given three dimensional conformal hypo fractionated high dose radiotherapy, 400cGy/fractionation, 14fractions, the total dose of 56Gy in a course of 18～21days; and they were also given concurrent the low dose density TP chemotherapy, 4～6 peri...
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