bcl-2和p16蛋白在食管鳞癌组织中的表达及其意义

Expression and significance of bcl-2 and p16 protein in esophageal squamous cell cancer and their surrounding tissues

摘要: 目的　研究凋亡相关基因bcl 2和抑癌基因 p16在食管鳞癌及癌旁组织中的表达及意义。方法应用SP法, 检测 4 0例食管鳞癌及癌旁组织中bcl 2和p16蛋白的表达。结果　bcl 2在正常食管粘膜、单纯增生、不典型增生及鳞癌组织中表达率分别为 6 %、6 3.3%、4 6 .5 %和 4 2 .5 %, 正常粘膜组与其余各组之间有显著性差异 (P <0 .0 1) ;bcl 2表达与病理分级、浸润深度及淋巴结转移无相关性。p16蛋白在正常食管粘膜上皮、单纯增生、不典型增生、鳞癌组织中的表达呈递减的趋势 (P <0 .0 1)。p16表达与病理分级、浸润深度及淋巴结转移相关。结论　bcl 2与 p16在食管鳞癌发生的不同时期起作用, bcl 2可作为食管癌发生的早期判断指标。p16蛋白的缺失与食管鳞癌的发生及恶性进展有关, 检测 p16蛋白可能成为判断食管鳞癌预后的一个指标。

Abstract: Objective To study the expression and significance of bcl-2 and p16 in esophageal squamous cell cancer and the surrounding tissues. Methods S-P method was used to examine the expression of bcl-2 and p16 in 40 esophageal squamous cell cancer and the surrounding tissues. Results Expression of bcl-2 was 6%, 63.3%, 46.5% and 42.5% in normal esophageal mucosa, atypical hyperplasia, and squamous carcinoma tissues, respedively. There were significant differences between normal esophageal mucosa and ot...