乳腺癌p16、PS2基因表达与多药耐药的相关分析

Relationship between expression of p16、PS2 and multidrug resistance in breast cancer

摘要: 目的　探讨乳腺癌中 p16、PS2与GST Pi、TOPOⅡ、PgP表达意义及相关性。方法　用即用型微波加热免疫组化法对 5 7例乳癌进行p16、PS2、GST Pi、TOPOⅡ、PgP检测分析。结果　 5 7例乳癌的阳性率依次为 36 .84 %、77.19%、5 2 .6 3%、2 4 .5 6 %、15 .79%。结论　乳癌产生多药耐药性可能与 p16、PS2异常表达相关。部分乳癌患者体内存在多项耐药基因或癌细胞内原发存在对GST Pi、TOPOⅡ、PgP介导的抗癌药物耐药。

Abstract: Objective To explore the relationship between expression of p16、PS2 and Resistance genes of GST-Pi、TOPOII、 PgP in breast cancer. Methods The detection and analysis of p16、PS2、GST-Pi、TOPOII、PgP genes proteins in 57 breast cancer were made by using the Instant Microwave heating-immunohistochistry technique. Results The positive expression rate of p16、PS2、GST-Pi、TOPOII、PgP are 36.84% 77.19%, 52.63%, 24.56%, 15.79%, respectively in breast cancer of 57 cases. Conclusion Abnorm...