IPED方案治疗难治性非何杰金氏淋巴瘤的近期疗效

Short-term effect of IPED regimen in treatment of refractory Non-Hodgkun s lymphoma

摘要: 目的　观察由异环磷酰胺 (IFO)、足叶乙甙 (VP 16 )、顺铂 (DDP)和地塞米松 (DXM )组成的联合方案 (IPED方案 )治疗难治性非何杰金氏淋巴瘤的近期效果和毒副作用。方法　 2 1例难治性非何杰金氏淋巴瘤均采用IPED方案进行化疗, 每 2 8天重复, 每例至少进行化疗 2个周期, 治疗结束后评价疗效。结果　CR 5例, PR 10例, SD 3例, PD 3例, 总有效率为 71.4 %, 毒副作用主要为骨髓抑制和消化道反应。结论　IPED方案是治疗难治性非何杰金氏淋巴瘤效果较好、毒副反应可以耐受的联合化疗方案。

Abstract: Objective To observe the effect and toxicity of IPED regimen in treatment of refractory Non-Hodgkin s Lymphoma. Methods All 21 patients were treated over two cycles with IPED regimen. The IPED regimen was repeated every 28 days. The therapeutic effect was observed after treatment. Results 5 patients achieved complete remission(CR), 10 partial remission(PR) 3 stable disease(SD),3 progression disease(PD). The overall response rate was 71.4%.The main side effects were myelosuppression and gastrointest...