Abstract: Objective 　To investigate the comprehensive treatment for locally advanced gastric carcinoma. Methods 　32 patients with local advanced gast ric carcinoma were included into the study, received 2～3 cycles of 5-Fu-based chemotherapy followed by three-dimensional conformal radiation therapy (3DCRT) combined with chemotherapy of 5-Fu 500 mg/ (m² ·d), int ravenous drip infusion for 24h, one time per week for successive five weeks, calcium folinate 200 mg/ (m² ·d), int ravenous drip infusion for 24 h, one time per week for successive five weeks. Results 　32 patients were eligible for the analysis. The overall survival rates of 1, 3, 5 year were 90. 6 %, 56. 3 %, 37. 5 % respectively, and the local-control rates were 53. 1 %、28. 1 %、15. 6 % respectively. The major adverse effect s were acute gast rointestinal reactions and granulocytopenia (chiefly grade Ⅰ～ Ⅱ) . Conclusion 　The therapy of 3DCRT plus induction chemotherapy based on 5-Fu weekly followed by induction chemotherapy was feasible for the treatment of local advanced stomach cancer. It could increase the local-cont rol rate, elongation the survival time and the adverse effect s were tolerable.