Abstract: Objective 　To study the expression level of CD105, MMP-2 and MMP-9 in giant cell tumor of bone and to detect the correlation between their expression levels and tumor recurrence. Methods 　The expressions of CD105, MMP-2 and MMP-9 in 38 cases of giant cell tumor of bone were studied by using SP immunohistochemical method. Their relationship with clinicopathological features and tumor recurrence after operation was analysed too. Results 　(1) The average value of MVD in tumor was 9. 70 ±2. 34, which was much higher in aggressive type cases than in quiescent type ( P < 0. 05) . Recurrent cases had higher MVD value than cases without recurrence( P < 0. 01), yet was not associated with histological grade ( P > 0. 05) . (2) The expression ratio of MMP-2 was 47. 37 %. Recurrent cases had higher positive rate than cases without recurrence ( P <0. 05) . No distinct difference of the expression ratio was found among cases of different histological grade and radiological type ( P > 0. 05) . (3) Positive rate of MMP-9 was 60. 53 %. No distinct difference of the expression level of MMP-9 was found among cases of different histological grade ( P > 0. 05) . Tumors of aggressive type and active type had higher positive rate than quiescent type cases ( P < 0. 01), and recurrent cases had higher positive rate than cases without recurrence ( P < 0. 01) . (4) MMP-2 positive cases had higher MVD than MMP-2 negative cases ( P < 0. 01), MMP-9 positive cases had higher MVD than MMP-9 negative cases ( P < 0. 01) . Conclusion 　MVD counted with CD105 and overexpression of MMP-2 and MMP-9 could be used as objective prognostic indicators of tumor recurrence. Angiogenesis in tumor might be promoted by the overexpression of MMP-2 and MMP-9.