Abstract: Objective 　The objective of this study is to detect the expression of VEGF-C in Non-Small Cell Lung Cancer, and to explore their association with invasion lymph metastasis hemagenous metastasis and prognosis. Methods 　A rapid immunohistochemical method ( streptoavidin-peroxidase SP) was used to detect VEGF-C proteins expression in 43 cases of Non-Small Cell Lung Carcinoma, these cases were not treated radiotherapy or chemotherapy before operation. Results 　The expression rates of VEGF-C in lung squamous cell carcinoma and lung adenoccarcinoma were 54. 16 %, 84. 21 % respectively. The positive expression of VEGF-C were significantly correlated with lympha node metastasis, TNM stage and postoperative hematogenous metastasis ( P = 0. 01) The 32year, 52year survival rates of VEGF-C positive groups were 24. 43 %, 18. 75 %, The 32 year 52 year survival rates of VEGF-C negative expression groups were 64. 71 %, 58. 82 %, There were significant difference of survival time between VEGF2C positive expression and VEGF-C negative expression groups ( P < 0. 05) . Conclusion 　VEGF-C may play a role in invasion, lympha node metastasis, postoperative hematogenous metastasis and prognosis.