肿瘤标志物在肺癌诊断、疗效及预后评判中的意义

The Clinical Value of Tumor Makers in the Diagnosis, Prediction Response to Chemotherapy and Prognosis in Human Lung Cancer

摘要: 目的　评价肿瘤标志物在肺癌诊断、疗效及预后中的临床价值。方法　采用放射免疫法检测 1 98例肺癌和 6 1例肺部非癌症疾病住院患者治疗前、后血清癌胚抗原 (CEA)、神经元特异性烯醇化酶 (NSE)、细胞角质蛋白 1 9片段 (Cy FRA2 1- 1)水平, 然后进行分析和评价。结果　肺癌患者血清 CEA、NSE、Cy FRA2 1- 1水平明显高于肺部非癌症患者组, 其中腺癌患者血清 CEA水平最高, 小细胞肺癌患者血清 NSE水平最高, 鳞癌患者血清 Cy FRA2 1- 1水平最高。结论　测定肺癌患者血清 CEA、NSE、Cy FRA2 1- 1水平对肺癌的诊断、疗效及预后评判有比较重要的临床意义.

Abstract: Objective To evaluate the clinical value of tumor markers on diagnosis,response to chemotherapy and prognosis in human lung cancer. Methods The serum levels of CEA,NSE and CyFRA\-\21-1\ were assayed by radioimmunoassay before treatment and after treament in 198 lung cancer patients. Results The CEA,NSE and CyFRA\-\21-1\ levels were higher in lung cancer patients compared with benign patients group.The CEA level were the highest in adenocarcinoma patients.The NSE level were the highest in small cell lung can...