新辅助化疗在Ib～IIb期宫颈癌病例中的作用

Neoadjuvant chemotherapy in stage Ib～IIb carcinoma of the cervix:long-term follow-up

摘要: 目的　探讨 1周期的新辅助化疗在宫颈癌病例治疗中的作用和地位。方法　 4 9例Ib～IIb期宫颈癌病例在实施宫颈癌根治术前给予 1周期新辅助化疗组 (NAC)。结果　临床有效率 6 1.2 2 %。病理证实的完全缓解 2例。平均生存时间 4 4月。结论　 1周期的新辅助化疗能够产生较高的有效率, 提高IIb期宫颈癌病例的手术成功率。对缺乏放疗设备的医疗单位, 我们可以用NAC代替后装腔内治疗。

Abstract: Objective To determine the role of neoadjuvant chemotherapy (NAC)) before radical Wertheim hysterectomy. Methods Fouty-nine previously untreated patients with stage Ib～IIb were enrolled in the study. Results The overall clinical response rate was 61.22% . Pathologic complete responses were found in 2 patients ( 4.08% ). The median survival time was 44 months in NAC treatment patients and as for survival time and survival rate there is no significant difference between two groups. Conclusion These prel...