Abstract: Objective In this paper, our purpose is to explore the effect of changes of development and differentiation genes in the malignant progression of glioma. Methods Exploiting the key genes of transcriptional regulation of tumor genesis and malignant progression by cDNA microarray is an important method at genomic research field. Detecting the gene expression patterns of primary and two recurrent glioma specimens compared with normal brain tissue of a same individual patient by using cDNA microarray and establ...