uPA、uPAR、nm23-H1在大肠癌中的表达及其与肿瘤侵袭和转移的关系

Expression of uPA, uPAR, nm23-H1 in Human Colorectal Cancer and Its Relation to Tumor Invasion and Metastasis

摘要: 目的探讨尿激酶型纤溶酶原激活剂(uPA)、尿激酶型纤溶酶原激活剂受体(uPAR)和nm23H1基因蛋白在大肠癌中的表达及其与肿瘤侵袭和淋巴结转移的关系。方法应用免疫组化SABC法,对121例大肠癌手术根治标本进行uPA、uPAR和nm23H1基因蛋白测定。结果uPA、uPAR和nm23H1阳性表达率分别为62%、74%和48%。uPA和uPAR高表达与大肠癌侵袭和淋巴结转移关系密切(P<0.05)。nm23H1基因蛋白的低表达与大肠癌分化程度和淋巴结转移密切相关(P<0.05)。大肠癌中uPA和nm23H1蛋白表达呈负相关(P<0.05)。结论uPA、uPAR和nm23H1基因蛋白表达与大肠癌侵袭和转移有显著相关性;同时检测uPA和nm23H1表达状况,可作为预测大肠癌淋巴结转移及预后的有用指标。

Abstract: Objective To investigate the expression of urokinase type plasminogen activator(uPA), uPA receptor(uPAR) and nm23 H1 gene protein in human colorectal cancer and its relationship with the invasion and lymph node metastasis. Methods SABC immunohistochemical method was used to detect the uPA, uPAR and nm23 H1 gene protein expression in 121 cases with human colorectal cancer after the surgical treatment. Results The expression rate of uPA, uPAR and nm23 H1 in 121 cases were 62%, 74% and 48% respectively. A signif...