Abstract: Objective To investigate the role of microvessel count,cyclin E,p53,CD44s and CD44v6 to predict the prognosis of gastric cancer. Methods In 95 gastric cancer patients,the above 5 indexes were examined by immunohistochemical method,and their clinicopathological features were investigated at the same time;then the correlation of each factor with prognosis,lymphatic invasion and venous invasion were examined,respectively. Results Microvessel count and cyclin E expression significantly affected the prognosis of gastric cancer patients.The expression of p53,CD44s and CD44v6 did not significantly affected the prognosis.Microvessel count was a significantly independent prognostic factor.The relative risk of lymphatic vessel invasion raised significantly as microvessel count increased.The relative risk of lymph node metastasis also raised significantly when p53 expression was positive.The relative risk of venous invasion did not increase significantly as the 5 indexes overexpressed or augmented. Conclusion In gastric cancer,microvessel count is a important index to predict patient's prognosis;cyclin E expression also plays some prediction role;the expression of p53,CD44s and CD44v6 do not have the role to predict prognosis.