高级搜索

吉西他滨联合奥沙利铂和强的松治疗复发性或难治性非霍奇金淋巴瘤20例报告

陆文斌, 金建华, 杨玉薇, 王芳, 李献文, 张华, 顾小燕

陆文斌, 金建华, 杨玉薇, 王芳, 李献文, 张华, 顾小燕. 吉西他滨联合奥沙利铂和强的松治疗复发性或难治性非霍奇金淋巴瘤20例报告[J]. 肿瘤防治研究, 2008, 35(02): 121-123. DOI: 10.3971/j.issn.1000-8578.2035
引用本文: 陆文斌, 金建华, 杨玉薇, 王芳, 李献文, 张华, 顾小燕. 吉西他滨联合奥沙利铂和强的松治疗复发性或难治性非霍奇金淋巴瘤20例报告[J]. 肿瘤防治研究, 2008, 35(02): 121-123. DOI: 10.3971/j.issn.1000-8578.2035
LU Wen-bin, JIN Jian-hua, YANG Yu-wei, WANG Fang, LI Xian-wen, ZHANG Hua, GU Xiao-yan. Effect of Gemcitabine Plus Oxaliplatin and Prednisone(GPP) in Treatment of Fwenty Patients with Relapsed or Refractory Non-hodgkin s Lymphoma[J]. Cancer Research on Prevention and Treatment, 2008, 35(02): 121-123. DOI: 10.3971/j.issn.1000-8578.2035
Citation: LU Wen-bin, JIN Jian-hua, YANG Yu-wei, WANG Fang, LI Xian-wen, ZHANG Hua, GU Xiao-yan. Effect of Gemcitabine Plus Oxaliplatin and Prednisone(GPP) in Treatment of Fwenty Patients with Relapsed or Refractory Non-hodgkin s Lymphoma[J]. Cancer Research on Prevention and Treatment, 2008, 35(02): 121-123. DOI: 10.3971/j.issn.1000-8578.2035

吉西他滨联合奥沙利铂和强的松治疗复发性或难治性非霍奇金淋巴瘤20例报告

详细信息
  • 中图分类号: R33 ; R730. 53

Effect of Gemcitabine Plus Oxaliplatin and Prednisone(GPP) in Treatment of Fwenty Patients with Relapsed or Refractory Non-hodgkin s Lymphoma

  • 摘要: 目的观察低剂量吉西他滨24小时持续静脉滴注联合奥沙利铂、强的松(GPP方案)治疗复发性及难冶性非霍奇金淋巴瘤(NHL)的近期疗效。方法20例复发性及难治性NHL患者,应用GPP方案,即:Gem 120mg/m^2,24小时持续静脉滴注,d1.8,L—OHP 80mg/m^2,静脉滴注,d1.8;PDN60mg/m^2,口服,d1~5;21d为1周期,完成2周期以上者做疗效评价。结果20例患者中,CR6例,PR8例,NC3例,PD3例,总有效率(CR+PR)为70%。结论GPP方案治疗复发性及难治性NHL的近期疗效满意,毒性反应可耐受。

     

    Abstract: Objective  To evaluate the short2term efficacy of low2dose Gemcitabine 24 h continuous infu2 sion plus Oxaliplatin and Prednisone ( GPP) regimen in the t reatment with relapsed or ref ractory non2 Hodgkin's lymphoma (N HL) . Methods  Twenty cases with relapsed or ref ractory N HL were t reated with GPP regimen : Gem 120 mg/ m2, 24 h continuous infusion, d1, 8 ;L2OHP 80 mg/ m2, ivgtt, d1, 8 ; PDN 60 mg/m2, p . o, d1~5 ; Every 21 days is one cycle. Their clinical response was assessed af ter 2 cycles of chemo2 therapy. Results  In the 20 cases, the complete response was 6 cases, the partial response was 8 cases, 3 cases was no change, 3 case was progressive, the overall response rate (CR + PR) was 70 %. Conclusion  GPP regimen can achieve a satisfied result in the t reatment of relapsed or ref ractory N HL, and the toxici2 ty was endurable.

     

计量
  • 文章访问数: 
  • HTML全文浏览量:  0
  • PDF下载量: 
  • 被引次数: 0
出版历程
  • 收稿日期:  2006-12-18
  • 修回日期:  2007-03-01
  • 刊出日期:  2008-03-04

目录

    /

    返回文章
    返回
    x 关闭 永久关闭