Abstract: Vascular endothelial growth factor (VEGF) inhibitors are drugs that target and inhibit tumor angiogenesis. By blocking the VEGF/VEGFR signaling pathway, they suppress tumor proliferation and play a significant role in tumor treatment. However, the related toxic and side effects during its treatment process (such as hypertension, hand-foot skin reactions, and bone marrow suppression) seriously affect patients' treatment compliance and quality of life. Exploring intervention strategies for adverse reactions of VEGF inhibitors is of great significance for tumor treatment. This article reviews the clinical characteristics and toxic mechanisms of common adverse reactions such as hypertension, hand-foot skin reactions, and bone marrow suppression caused by VEGF inhibitors during tumor treatment, and summarizes targeted intervention strategies combining traditional Chinese and Western medicine. Precise monitoring and adjustment of drug dosages are carried out to achieve the goal of anti-tumor treatment. Targeted improvement of patients' discomfort symptoms is achieved through prescriptions such as tonifying qi and promoting blood circulation, strengthening the spleen and tonifying the kidney. The combination of traditional Chinese and Western medicines is used to treat patients, providing a safer and more effective treatment plan for cancer patients.