Abstract: Objective To study the relationship between symptom burden and nutritional status under TCM constitution classification in chemotherapy patients to guide nutritional management. Methods The physical constitution, symptom burden and nutritional status of 640 patients with malignant tumors within the 21st to 28th days of chemotherapy treatment were collected and analyzed. Results There was a positive correlation between symptom burden and nutritional risk and TCM bias (except for idiosyncrasies), suggesting that constitution bias may be an important internal factor for the aggravation of clinical symptoms and malnutrition in cancer patients. Conclusion The relationship between symptom burden and nutritional status in chemotherapy under the guidance of traditional Chinese medicine constitution can be studied to predict the nutritional status and symptom burden of patients after chemotherapy, so as to guide the symptoms and nutritional management of cancer patients in the chemotherapy stage.