Abstract: PurposeTo analyze the epidemiological characteristics and disease burden of malignant tumors in Shijiazhuang in 2021.MethodsAccording to the tumor data reported by cancer registration areas in Shijiazhuang in 2021, The crude incidence/mortality rates, age-standardized incidence/mortality rates(ASIR/ASMR)were calculated to analyze the incidence and mortality of malignant tumors in Shijiazhuang in 2021.the disability-adjusted life years (DALYs), years of life lost (YLLs) and years lived with disability(YLDs) were calculated to estimate the disease burden of malignant tumors.ResultsIn 2021, there were 13250 new cancer cases in cancer registration areas of Shijiazhuang, the incidence rate was 275.50/10⁵ , the ASR China was 177.17/10⁵, the ASR world was 172.11/10⁵, the cumulative rate(0-74 years old)was19.57%.The age-specific incidence of malignant tumors reached its peak in age group of 80-84years old. there were 7165 deaths, The mortality rate was 148.98/10⁵, the ASR China was 85.13/10⁵ , the ASR world was 84.52/10⁵, the cumulative rate(0-74 years old) was 9.49%.The age-specific mortality of malignant tumors reached its peak in age group of above 85 years old.Lung caner and breast cancer were the most common malignant tumors in male and female.The DALY of malignant tumors in the cancer registration areas of Shijiazhuang city were 87725.29 person-years, and the DALY rate was 18.24‰. AMONG THESE, YLL were 85392.09 person years, accounting for 97.34%; YLD are 2333.19 person years, accounting for 2.66%.Lung cancer had the heaviest disease burden with DALY of 22687.12 person-years, accounting for 25.86% of all malignant tumors, followed by stomach, liver, colorectal and esophageal cancers. ConclusionCancers of Lung, liver, female breast, stomach and colorectum are the major healthy threats in Shijiazhuang.Malignant tumor brings heavy burden to residents of Shijiazhuang city, and premature death is the main source of disease burden.To decrease the disease burden of cancer, more attentions should be paid and preventive measures should be taken early.