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免疫检查点抑制剂在宫颈癌治疗中的研究新进展

Recent Advances of Immune Checkpoint Inhibitors in Treatment of Cervical Cancer

  • 摘要: 免疫检查点抑制作为当今临床研究的热点,在晚期宫颈癌一线及二线治疗中均有指南推荐,或免疫单药,或联合治疗,临床实践中也取得了不错的疗效。在局部晚期宫颈癌中,免疫检查点抑制剂刚被纳入指南的辅助治疗中,临床上也取得了良好的肿瘤退缩效果。已有研究结果显示,免疫检查点抑制剂作为新辅助治疗手段也展现出不错的临床治疗潜力。此外,越来越多的免疫治疗患者后续的再挑战问题也进入临床工作者的视野中,试图以此帮助既往接受过免疫治疗的宫颈癌患者,为其提供一种新的治疗选择。本文基于近年来免疫检查点抑制剂在宫颈癌治疗中的临床应用和研究进展进行总结,希望为临床治疗提供有价值的思路和方向。

     

    Abstract: As a hot spot in clinical research today, immune checkpoint inhibitor has been recommended by guidelines in the first- and second-line treatments of advanced cervical cancer as immune monotherapy or combination therapy. It has also achieved good efficacy in clinical practice. In locally advanced cervical cancer, immune checkpoint inhibitors have been included in the guidelines for adjuvant therapy, and good tumor regression effects have been achieved in clinical practice. Based on the results of existing trials, immune checkpoint inhibitors have also shown good clinical potential as neoadjuvant therapy. Furthermore, the issue of immunotherapy rechallenge has increasingly captured clinicians’ attention, offering a potential new therapeutic strategy for cervical cancer patients with prior immunotherapy exposure. In this article, the clinical application and research progress of immune checkpoint inhibitors in the treatment of cervical cancer in recent years are summarized to provide valuable ideas and directions for clinical treatment.

     

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