α-SMA和梭形细胞Vimentin的表达及其与黏液纤维肉瘤患者预后的关系

吴国慧; 张燕

doi:10.3971/j.issn.1000-8578.2025.25.0048

α-SMA和梭形细胞Vimentin的表达及其与黏液纤维肉瘤患者预后的关系

吴国慧,
张燕

Expression Levels of α-SMA and Vimentin in Spindle Cells and Their Relationship with Prognosis of Patients with Myxofibrosarcoma

摘要

摘要:
目的分析α-平滑肌肌动蛋白（α-SMA）和梭形细胞Vimentin的表达及其与黏液纤维肉瘤（MFS）患者预后的关系。
方法收集2018年1月至2021年1月在中国人民解放军总医院第四医学中心收治的61例MFS患者的影像学资料、临床及病理学资料，所有MFS患者均经术后病理学检查证实。免疫组织化学法测定MFS患者α-SMA和梭形细胞Vimentin的阳性比例并分析α-SMA和梭形细胞Vimentin表达与预后的相关性。
结果在MFS组织中α-SMA和Vimentin阳性表达率分别为68.85%和60.66%；Vimentin的表达与3年总生存期（OS）及无病生存期（DFS）无显著性相关（P=0.351，P=0.284），α-SMA的表达与OS、DFS显著相关（P=0.030，P=0.017），α-SMA高表达患者的OS、DFS较短。
结论测定α-SMA水平有助于评估MFS患者预后，从而指导临床治疗。

Abstract:
Objective To analyze the expression levels of a-smooth muscle actin (α-SMA) and Vimentin in spindle cells and their relationship with the prognosis of patients with myxofibrosarcoma (MFS).
Methods The imaging, clinical, and pathological data of 61 patients with MFS were collected. All patients were confirmed by surgical and postoperative pathological examination. Immunohistochemical methods were used to determine the positive proportion of α-SMA and Vimentin. The correlation between the expression levels of α-SMA and Vimentin in spindle cells and prognosis was analyzed.
Results The positive rates of α-SMA and Vimentin expression in MFS tissues were 68.85% and 60.66%, respectively. The expression of Vimentin was not significantly correlated with 3-year OS and DFS (P=0.351, P=0.284). The expression of α-SMA was significantly correlated with OS and DFS (P=0.030, P=0.017), and patients with high expression of α-SMA have shorter OS and DFS.
Conclusion Determining α-SMA level can help evaluate the prognosis of patients with MFS and guide clinical treatment.

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