Abstract:
Objective To evaluate the effect of thermal tomography in breast cancer (BC) screening. Methods We conducted a general population-based BC screening in three regions of Hubei province (Xiantao district, Hongan district, Yangxin district). Participants received a questionnaire-based interview for baseline data collection. Then, the participants were undergone physical examination, thermal tomography, and ultrasound by doctors and technicians. We compared the efficacy between ultrasound and thermal tomography for BC screening including sensitivity, specificity, false positive rate. Results 59712 eligible women were included for this screening program. The BI-RADS 1, 2, 3, 4, and 5 accordance rates between the two screening methods were 0.9549, 0.8047, 0.9037, 0.3352, and 0. The overall accordance rate was 0.9331. The Kappa consistency results showed that Cicchetti-Allison and Fleiss-Cohen Kappa value were 0.7970 and 0.8583 respectively. The sensitivity was equal between two methods, but the specificity was higher in thermal tomography than in ultrasound. False positive rate was lower in thermal tomography than in ultrasound. The area under the receiver operating characteristic (ROC) curve of thermal tomography was significantly larger than that of ultrasound. Conclusion The general consistency between thermal tomography and ultrasound in BC screening was high. Thermal tomography outbalance ultrasound in specificity, and diagnostic efficiency. Therefore, thermal tomography has a high application value for general population-based BC screening.
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