Abstract: In response to the clinical needs of cancer treatment and rehabilitation, based on years of clinical experience and the Guben Qingyuan (consolidate the foundation and clear the source) theory, Professor Lin Hongsheng proposed the Wuzhi Wuyang (five treatments and rehabilitation) concept. The Wuzhi Wuyang (five treatments and rehabilitation) emphasize the importance of both treatment and rehabilitation, and aim to provide personalized and stage-specific treatment and rehabilitation plans by integrating the advantages of traditional Chinese medicine (TCM) and conventional medicine to achieve the goal of comprehensive life-cycle management for patients with cancer. The proposal of the Wuzhi Wuyang (five treatments and rehabilitation) has provided new ideas and methods for the prevention and rehabilitation of cancer, and has provided valuable references for clinical practice and academic research. The present article summarizes the connotation of Wuzhi Wuyang (five treatments and rehabilitation) and its application in the comprehensive management of cancer prevention and treatment with TCM.