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宫颈癌代谢组学的研究现状与进展

Status and Progress of Research on Metabolomics of Cervical Cancer

  • 摘要: 宫颈癌是我国最常见的妇科恶性肿瘤之一。由于早期症状不明显,半数以上患者就诊时已处于中晚期,预后不佳,寻找新的治疗靶点是目前的研究方向。代谢组学作为一门新兴的组学技术,可通过色谱、质谱等方法分析肿瘤发生发展过程中代谢物的变化及潜在机制,有望为肿瘤精准诊疗提供新靶点。本文分别从代谢组学研究方法、宫颈癌代谢特征以及代谢组学在宫颈癌诊断、疗效预测、预后评估等方面的研究进展进行综述,以期为宫颈癌精准诊疗提供新思路。

     

    Abstract: Cervical cancer is one of the most common gynecological malignant tumors in China. Given their lack of obviously early symptoms, more than half of patients with cervical cancer are diagnosed in the middle and late stages of this malignancy, resulting in poor prognosis. Finding new therapeutic targets is the current research direction. Metabolomics, as a new omics technology, is expected to provide new targets for tumor precision diagnosis and treatment through the analysis of the changes and potential mechanisms of metabolites in tumor occurrence and development by chromatography, mass spectrometry, and other technologies. Herein, we review the research methods of metabolomics; metabolic characteristics of cervical cancer; and progress of the research on metabolomics in cervical cancer diagnosis, curative effect prediction, and prognosis evaluation to provide new ideas for the precise diagnosis and treatment of cervical cancer.

     

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