Abstract:
Metastasis is a key cause of death in tumor patients, and a large number of tumor patients have comorbid psychosomatic abnormalities, they are in a state of chronic stress. Chronic stress affects the release of many kinds of hormones and neurotransmitters, such as epinephrine, norepinephrine, dopamine, glucocorticoids, cortisol, sex hormones, etc., through the hypothalamus-pituitary-adrenal axis and sympathetic nervous system, which can act on the β-adrenergic receptor, glucocorticoid receptor, etc., on tumor cells, immune cells and other cells in the tumor microenvironment, and promote the tumor angiogenesis by directly enhancing the invasive and metastatic ability of tumor cells, inducing the formation of immunosuppressive microenvironment, promoting tumor angiogenesis and other pathways to promote tumor progression and metastasis. Based on the above mechanisms, antipsychotic drugs, β-blockers, and glucocorticoid receptor antagonists have inhibitory effects on chronic stress-mediated tumor metastasis and have achieved certain clinical efficacy. In addition, relevant studies have been carried out on traditional Chinese medicine decoctions and monomers, which can inhibit tumor metastasis by modulating the immune microenvironment and reversing chronic stress-mediated hormonal changes. The psychological problems of tumor patients have gradually received attention, and the development of new anti-metastatic drugs based on the mechanism of action of chronic stress in promoting tumor progression and metastasis provides new ideas for the improvement of the overall efficiency of tumor prevention and treatment.
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